Vaping Equivalents: How Many Puffs of Vape Equal One Cigarette? Flavourless 50VG 50PG (30mL) by DV Labs Did you know some vapes contain up to 50mg of nicotine? That's about the same as smoking 50 cigarettes. Nicotine is toxic and can lead to acute lung injury. Stay informed and 1 electronic cigarette pod is roughly equal to 20 cigarettes' worth of nicotine, or 200 puffs. That's a lot! Make the choice not to let nicotine control your life. #EliminateTobacco and put 50mg Vape Juice Vape Shack