Acetaminophen metabolism Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Acetaminophen Pathway (toxic doses), Pharmacokinetics The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect