Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society Frontiers The global role of G6PD in infection and immunity G6pd glucose6phosphate dehydrogenase pathway vector illustration graphic Premium Vector Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No