Glutathione in liver diseases and hepatotoxicity. Semantic Scholar Dysregulation of glutathione synthesis in liver disease ScienceDirect The Liver: Inflammation, Oxidative Stress, and Glutathione Synthesis IMMA Immunity Matters Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis ScienceDirect Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes