Paracetamol toxicity Biochemical Basis Lecture Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.