As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower N acetylcysteine (NAC) g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Sex differences in glutathione metabolism and acetaminophen toxicity Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health