Glucose 6 phosphate Dehydrogenase deficiency (G6PD deficiency) Labpedia.net Role of G6PD in managing oxidative stress Glutathione peroxidase Download Scientific Diagram HEMOLYTIC ANEMIA Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst