Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Pathology of G6PD deficiency Pathology Made Simple Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page Glucose 6 phosphate dehydrogenase (G6PD): Response of the human erythrocyte and another cells to the decrease in their activity