Pediatric Implications of Normal Insulin GH IGF Axis Physiology Endotext NCBI Bookshelf How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Interrelationship between growth hormone (GH), insulin like growth Download Scientific Diagram Pharmacogenomics of insulin like growth factor I generation during GH treatment in children with GH deficiency or Turner syndrome The Pharmacogenomics Journal The GH IGF 1 axis in obesity: pathophysiology and therapeutic considerations Nature Reviews Endocrinology