A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Nature Chemical Biology G6PD and the glutathione (GSH) cycle. Download Scientific Diagram Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Pharmacological targeting of glucose 6 phosphate dehydrogenase in human erythrocytes by Bay 117082, parthenolide and dimethyl fumarate Scientific Reports