A major breakthrough in brain science is shedding new light on the biology behind depression. Using advanced imaging, researchers have found that people with major depressive disorder have significantly lower levels of Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation Scientific Reports PDF) GlutathioneRelated Metabolite Levels and Enzyme Activities in Depression: A Systematic Review and MetaAnalysis Depression, Genetics, and Mitochondrial Function Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Cell Death & Disease