Melanotic neuroectodermal tumor of infancy Wikipedia Freckle on Lip: Meaning, Causes and Is It Dangerous? (Labial Melanotic Macule) La Bouche Parfaite Clinical features of cutaneous melanotic nevihead and neck region. a Download Scientific Diagram Vulvar Melanotic Macules DoveMed Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells.