Application of glutathione depletion in cancer therapy: Enhanced ROS based therapy, ferroptosis, and chemotherapy ScienceDirect Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic A glutathione depleted prodrug platform of MnO2 coated hollow polydopamine nanospheres for effective cancer diagnosis and therapy New Journal of Chemistry (RSC Publishing) Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells Cell Death & Disease The reason some people stay sick despite treatment often comes down to one molecule. Glutathione is the most abundant antioxidant inside your cells. It protects mitochondria, recycles other antioxidants, and repairs